Postdoctoral position in ADP-ribosylation signaling & proteomics

A fully funded 2-year postdoctoral fellow position is available in the group of Professor Dr. Michael L. Nielsen, focusing on Proteomics Technology Development & Application, at The Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk). The center has been established at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied discovery research on human proteins of medical relevance. The center comprises a wide range of expertise and resources including proteomics, protein production, and characterization of disease mechanisms.

The Nielsen group focuses on developing novel proteomics technologies for detailing cellular outcomes in a systems-level approach, with the aim to improve current understanding of cellular phenotypes and diseases. To this end, the selected candidate will employ cutting-edge mass spectrometry (MS)-based strategies for identification and quantification of post-translational modifications (PTMs).

Project Description

The entailed project will focus on applying systemic proteomic strategies for investigations into the cellular consequences and biological processes related to ADP-ribosylation, and the enzymatic machinery responsible for the dynamic regulation of the modification. The Nielsen lab has pioneered the Af1521 enrichment strategy for studying ADP-ribosylation across cells, tissue samples, model systems, or patient material to gain novel insights into the molecular mechanisms surrounding this emerging PTM. The ideal candidate is expected to apply our proteomic technologies to address challenging biological questions, and to make a strong scientific impact in the ADP-ribosylation field, and related research areas. To achieve this, we are looking for a candidate with an excellent publication record that will thrive in a supportive and multi-disciplinary environment.

Estimated start date: Summer/Autumn, 2022.

Qualifications

• The candidate is required to have PhD or equivalent degree.
• Excellent scientific track record, including at least one first-author publication in a high quality, peer reviewed international journal.
• Prior experience with studying ADP-ribosylation or PARP biology will be considered a distinct advantage.
• Knowledge in one or more of the following area(s) would be considered an advantage: molecular and cell biology, cell signaling, chromatin biology, proteomics, or Systems biology
• Experience with mass spectrometry-based proteomics, or complementary methodologies like microscopy, will be considered an advantage.
• The candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills.
• Good communication skills, both oral and written.
• An analytical aptitude for devising innovative scientific or technical solutions.
• Demonstrate enthusiasm, motivation, flexibility and confidence.

 

Place of employment and work

The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The research environment at CPR is vibrant, ambitious, and international, with approx. 30 different nationalities currently represented. The center comprises modern laboratories and state-of-the-art facilities within protein science. Seminars with high-profile international speakers and regular internal research seminars are organized at CPR.

Terms of salary and employment

The employment as postdoc is a full-time position for 2 years. Starting date is August 1, 2022, or after agreement. Salary, pension, and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Application

Your application should be submitted electronically, and your application should include the following documents:

1. Motivated letter of application, including an outline for research projects of interest.
2. Curriculum vitae, incl. education and experience
3. List of publications
4. Letters of recommendation
5. Names and contact details for two referees

 

For further information about the position, please contact CPR: [email protected]

Deadline for application: April 24th, 2022